Cholic Acid

Research use only, not for human use.

ApplicationNon-denaturing ionic detergent used for extraction of membrane proteins.

ApplicationNon-denaturing ionic detergent used for extraction of membrane proteins. (In Vitro):Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway.(In Vivo):Cholic acid (1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity.

Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway.

Cholic acid(1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity. Animal Model:Tg-CYP2D6 adult male mice (8 weeks of age and weighing 20–25 g) Dosage:1% (w/w) Cholic acid-supplemented diet Administration:Oral, 14 days Result:Decreases SHP expression and increased CYP2D6 activity.

Cholalic Acid | Cholalin | NSC 6135

Others

Other Targets

Others

Other Indications

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81-25-4

408.58

C24H40O5

>98% (HPLC)

DMSO: 10 mM

C[C@@]12[C@@H](C(C)CCC(O)=O)CC[C@@]1([H])[C@]3([H])[C@H](O)CC4C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@@H]2O

4-((3R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

(-20℃)

With Ice Pack

≥ 2 years