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Cholic Acid

CAS No. 81-25-4

Cholic Acid( Cholalic Acid | Cholalin | NSC 6135 )

Catalog No. M16037 CAS No. 81-25-4

ApplicationNon-denaturing ionic detergent used for extraction of membrane proteins.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cholic Acid
  • Note
    Research use only, not for human use.
  • Brief Description
    ApplicationNon-denaturing ionic detergent used for extraction of membrane proteins.
  • Description
    ApplicationNon-denaturing ionic detergent used for extraction of membrane proteins. (In Vitro):Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway.(In Vivo):Cholic acid (1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity.
  • In Vitro
    Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway.
  • In Vivo
    Cholic acid(1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity. Animal Model:Tg-CYP2D6 adult male mice (8 weeks of age and weighing 20–25 g) Dosage:1% (w/w) Cholic acid-supplemented diet Administration:Oral, 14 days Result:Decreases SHP expression and increased CYP2D6 activity.
  • Synonyms
    Cholalic Acid | Cholalin | NSC 6135
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    81-25-4
  • Formula Weight
    408.58
  • Molecular Formula
    C24H40O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    C[C@@]12[C@@H](C(C)CCC(O)=O)CC[C@@]1([H])[C@]3([H])[C@H](O)CC4C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@@H]2O
  • Chemical Name
    4-((3R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wu Y, et al. J Biomed Nanotechnol. 2015 Jul;11(7):1247-60.
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